![]() ![]() However, ‘high-grade’ (≥30) MELD scores in ACLF indicate poorer prognosis after liver support treatment even LT –. Since model for end-stage liver diseases (MELD) score was used for organ allocation, candidates with ACLF have the priority to gain the donor liver and receive emergency LT because patients with ACLF usually have high MELD score. When ACLF progresses to multi-organ dysfunction such as hepatorenal syndrome and hepatic encephalopathy, the prognosis is dismal unless liver transplantation (LT), the only definitive therapy to salvage these patients, is performed. Most recently, these types of liver failure has been considered as acute-on-chronic liver failure (ACLF), which was clearly defined by Asian Pacific Association for the Study of the Liver as ‘acute hepatic insult manifesting as jaundice and coagulopathy, complicated within 4 weeks by ascites and/or encephalopathy in a patient with previously diagnosed or undiagnosed chronic liver disease’. Because of the high prevalence of hepatitis B, acute exacerbation of chronic hepatitis B and acute deterioration of cirrhosis are the most common causes of liver failure, contributing to especially high mortality in China. One-third of global individuals infected with hepatitis B virus (HBV) reside in China, with 130 million carriers, 30 million chronically infected, and 300 thousand per year HBV-related deaths –. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by the Chinese High Tech Research & Development (863) Program (2011AA020104), Science Fund for Creative Research Groups of the National Natural Science Foundation of China (81121002) and the Technology Group Project for Infectious Disease Control of Zhejiang Province (2009R50041). Received: OctoAccepted: DecemPublished: January 24, 2012Ĭopyright: © 2012 Ling et al. PLoS ONE 7(1):Įditor: Lise Lotte Gluud, Copenhagen University Hospital Gentofte, Denmark (2012) Downgrading MELD Improves the Outcomes after Liver Transplantation in Patients with Acute-on-Chronic Hepatitis B Liver Failure. The other authors either could not be reached or did not respond directly.Ĭitation: Ling Q, Xu X, Wei Q, Liu X, Guo H, Zhuang L, et al. One of the corresponding authors, Shusen Zheng, notified the journal that all authors disagree with the retraction. Owing to the lack of documentation to demonstrate that this study had prospective ethical approval, insufficient reporting, unresolved concerns around the source of transplanted organs and whether they included organs from prisoners, and in compliance with international ethical standards for organ/tissue donation and transplantation, the PLOS ONE Editors retract this article. The authors did not respond to inquiries about the availability of underlying data supporting this study. ![]() The authors stated that no vulnerable populations were involved in their research and all organs were obtained voluntarily but did not provide ethics approval documentation or consent forms to support their claim or clarify whether organs had been procured from prisoners. International ethical standards call for transparency in organ donor and transplantation programs and clear informed consent procedures including considerations to ensure that donors are not subject to coercion. ĭetails as to the donor sources and methods of obtaining informed consent from donors were not reported in, and when following up on these concerns the authors did not clarify these issues or the cause(s) of donor death in response to journal inquiries. Concerns have been raised that the transplants performed in the local context at the time of the procedures reported in this article may have involved organs/tissues procured from prisoners.
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